Copper(<scp>ii</scp>) chelates of a coumarin-based acyl hydrazone ligand: structural characterization and computational evaluations for prospective applications in antimicrobial, antiviral, antioxidant, and anticancer therapies

Abstract

release studies of CuH-silica composites confirmed controlled release behavior, supporting its potential as a nanodrug delivery system. Density Functional Theory (DFT) and molecular docking analyses corroborated the biological findings, with favorable interactions observed between the compounds and CDK2 kinase. Collectively, these results highlight CuH as a highly promising candidate for further preclinical evaluation, especially in cancer therapy, with silica-based dispersion enhancing its potential as a nanocarrier for targeted drug delivery.

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