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Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Xiaohui Zhang, Liang Chen, Biyun Zhu, Liren Wang, Caiyu Chen, Mengjia Hong, Yifan Huang, Huiying Li, Honghui Han, Bailian Cai, Weishi Yu, Shuming Yin, Lei Yang, Zuozhen Yang, Meizhen Liu, Ying Zhang, Zhiyong Mao, Yuxuan Wu, Mingyao Liu, Dali Li

2020Nature Cell Biology138 citationsDOI

Topics & Concepts

CytidineBiologyDNAComputational biologyCytidine deaminaseGenome editingBase pairGeneticsGeneCRISPRMolecular biologyBiochemistryEnzymeCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsVirus-based gene therapy research
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain | Litcius