Water-soluble polyphosphonate-based bottlebrush copolymers <i>via</i> aqueous ring-opening metathesis polymerization
Diego A. Resendiz‐Lara, Suna Azhdari, Hubert Gojżewski, André H. Gröschel, Frederik R. Wurm
Abstract
ROMP in water at neutral pH-values. This general protocol enabled the direct combination of PPEs with ROMP to synthesize well-defined bottlebrush polymers and block copolymers in water. Degradation of the PPE side chains was proven resulting in low molar mass degradation products only. The biocompatible and biodegradable nature of PPEs makes this pathway promising for designing novel biomedical drug carriers or viscosity modifiers, as well as many other potential applications.
Topics & Concepts
ROMPNorborneneCopolymerPolymerizationRing-opening metathesis polymerisationPolymer chemistryRing-opening polymerizationMolar massMonomerMetathesisPolymerDispersityChemistryGrubbs' catalystAqueous solutionMaterials scienceOrganic chemistrySynthetic Organic Chemistry Methodsbiodegradable polymer synthesis and propertiesChemical Synthesis and Analysis