Subcutaneous ertapenem delivered by an Australian outpatient parenteral antimicrobial therapy service: a retrospective comparative efficacy study
Jonathan Hiew, T Whitmore, Mahalia McEvoy, Deborah Weatherall, Paul R. Ingram, Laurens Manning
Abstract
Subcutaneous (SC) administration of ertapenem in outpatient parenteral antimicrobial therapy (OPAT) services may be a practical alternative to intravenous delivery for complicated infections. The clinical features and outcomes according to route of administration were compared from a large Australian OPAT service. Chronic renal impairment was more common in the SC group, reflecting an opportunity for route of administration as a vein preservation strategy. Adverse events were uncommon and successful outcomes were not different between the groups.
Topics & Concepts
MedicineErtapenemAntimicrobialIntensive care medicineRetrospective cohort studyAdverse effectRoute of administrationEmergency medicineAntibioticsSurgeryInternal medicineAntibiotic resistanceMeropenemOrganic chemistryChemistryMicrobiologyBiologyAntibiotics Pharmacokinetics and EfficacyCentral Venous Catheters and HemodialysisAntibiotic Use and Resistance