Pilot-scale co-precipitation synthesis of a novel active ingredient made of ultrasmall iron (oxyhydr)oxide nanoparticles for the treatment of hyperphosphatemia
Magdalena Teresa Spicher, Sebastian P. Schwaminger, Daniela von der Haar-Leistl, Marian Montiel Peralta, Georgina Mikacevic, F. E. Wagner, Sonja Berensmeier
Abstract
Ultrasmall iron (oxyhydr)oxide nanoparticles can be prepared with a yield >40 g L −1 on a pilot scale by co-precipitation without losing their exceptionally high phosphate-binding efficacy. Only slight changes in composition were observed, attributed to a reduction in core size.
Topics & Concepts
CoprecipitationPrecipitationNanoparticleOxideIngredientHyperphosphatemiaChemical engineeringMaterials scienceInorganic chemistryChemistryNanotechnologyMetallurgyPhosphateOrganic chemistryPhysicsEngineeringFood scienceMeteorologyIron oxide chemistry and applicationsIron Metabolism and DisordersBiomedical Research and Pathophysiology