CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis
Xianping Long, Zhimei Qiu, Chaofu Li, Yan Wang, Jiao Li, Ranzun Zhao, Jidong Rong, Ning Gu, Jinson Yuan, Junbo Ge, Bei Shi
Abstract
, respectively. Mechanistically, the transcription factor GATA4 promotes the production of circERBB2IP. Furthermore, circERBB2IP functioned as an endogenous miR-145a-5p sponge and was able to sequester and repress miR-145a-5p activity, which led to an increased expression level of Smad5. In summary, circERBB2IP can promote angiogenesis after myocardial infarction through the miR-145a-5p/Smad5 axis. These data suggest that circERBB2IP may be a potential therapeutic target for the treatment of myocardial infarction.
Topics & Concepts
Myocardial infarctionGene silencingAngiogenesisIn vivoRevascularizationTranscription factormicroRNAMedicinePathologicalCancer researchPsychological repressionCardiologyInfarctionCell biologyBiologyInternal medicineGene expressionGeneticsGeneCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research