Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching
Yu Zhao, Xiang-Yang Zhu, Turun Song, Lei Zhang, Alfonso Eirin, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Amir Lerman, Lilach O. Lerman
Abstract
Tumor necrosis factor-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of MSCs, but its ability to protect the ischemic kidney is unknown. In pigs with renal artery stenosis, we show that MSC delivery increased renal vein TSG-6, decreased kidney inflammatory macrophages, and improved renal function. In vitro, TSG-6 decreased inflammatory macrophages and tubular cell injury. Therefore, TSG-6 released from MSCs may decrease renal tubular cell injury, which is associated with regulating macrophage function and phenotype.
Topics & Concepts
Mesenchymal stem cellMacrophageTumor necrosis factor alphaKidneyLactate dehydrogenaseAdipose tissueInternal medicineFibrosisIn vivoEndocrinologyM2 MacrophagePathologyBiologyMedicineIn vitroBiochemistryEnzymeBiotechnologyTissue Engineering and Regenerative MedicineRenal and Vascular PathologiesRenal and related cancers