Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway
Shi‐Yong Zhu, Jianying Guo, Jinyang Li, Jinyang Li, Xueyan Dai, Xue‐Nan Li, Jin‐Long Li, Jin‐Long Li
Abstract
The study provides the novel insight that atrazine could induce pyroptosis in the spleen via inappropriately activating of the Nlrp3 inflammasome. However, lycopene ameliorated atrazine-induced pyroptosis by the inhibition of ox-mtDNA production.
Topics & Concepts
InflammasomePyroptosisOxidative stressChemistryAtrazineLycopeneCaspase 1SpleenReactive oxygen speciesCell biologyPharmacologyBiologyCarotenoidBiochemistryImmunologyPesticideReceptorAgronomyInflammasome and immune disordersGout, Hyperuricemia, Uric AcidHeme Oxygenase-1 and Carbon Monoxide