Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1
Tong Yang, Dandan Liu, Yulei Li, Ying Zhang, Yinhua Zhu, Junzhe Zhang, Chen Wang, Shujie Zhang, Yin‐Kwan Wong, Piao Luo, Qiuyan Guo, Fei Xia, Tianyu Zhong, Huan Tang, Jigang Wang
Abstract
, with potent anti-inflammatory activity. However, the mechanisms of action of Sof for treating intestinal-associated inflammation are not well known. In this work, we identified high mobility group box 1 (HMGB1) as the key covalent target of Sof for the anti-inflammatory activity in the human colonic epithelial cells through quantitative chemoproteomics profiling.
Topics & Concepts
Covalent bondChemistryHMGB1Cancer researchCaco-2BiochemistryIn vitroBiologyOrganic chemistryReceptorAdvanced Glycation End Products researchInflammatory mediators and NSAID effectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms