Microbiome-by-ethanol interactions impact Drosophila melanogaster fitness, physiology, and behavior
James Chandler, Lina Victoria Innocent, Daniel J. Martinez, Isaac Li Huang, Jane L. Yang, Michael B. Eisen, William B. Ludington
Abstract
, and paired this with the tractability of the fly gut microbiota, which can be experimentally removed. We linked numerous physiological, behavioral, and transcriptional variables to fly fitness, including a combination of intestinal barrier integrity, stored triglyceride levels, feeding behavior, and the immunodeficiency pathway. Our results reveal a complex tradeoff between lifespan and fecundity that is microbiome-dependent and modulated by dietary ethanol and feeding behavior.
Topics & Concepts
Drosophila melanogasterMicrobiomeDrosophila (subgenus)BiologyGut microbiomePhysiologyComputational biologyEcologyEvolutionary biologyBioinformaticsBiochemistryGeneInsect symbiosis and bacterial influencesInvertebrate Immune Response MechanismsInsect Utilization and Effects