Exposure Impacts of Diquat dibromide herbicide formulation on amphibian larval development
Oluwaseun Olusegun Babalola, Hannes Johannes van Wyk
Abstract
The formulation significantly reduced both the fore and hind limb lengths, and disrupted the developmental stage at concentrations of 0.11 and 0.14 mg/L, with a median at NF-stage 57, while median of NF-stage 60 was recorded in the control. Histopathologically, although there was no significant difference in thyroid gland area, the thyroid colloidal area was significantly reduced at 0.14 mg/L, while the mean height of the thyroid follicle increased at 0.05 mg/L The result indicates an extra-thyroidal pathway, due to the dissociation between stage developmental effects and thyroid histopathology. The role of stress pathway occasioned by oxidative mode of action, involving lipid peroxidation and cell damage observed in this study need further investigation, in order to further characterize the physiological and ecological effects on wildlife.