PEGylated Systems in Pharmaceutics
Natalia N. Porfiryeva, Rouslan I. Moustafine, Vitaliy V. Khutoryanskiy
Abstract
Abstract This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of various biological barriers and adhesion to mucosal tissues (mucoadhesion), are considered.
Topics & Concepts
PharmaceuticsMucoadhesionEthylene glycolPEG ratioDrug deliveryBiomoleculeLiposomePolyelectrolyteNanotechnologyChemistryDrugDrug carrierMaterials scienceBiophysicsPharmacologyPolymerOrganic chemistryMedicineBiologyEconomicsFinanceNanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery