Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4
Tengfei Huang, Tianqi Xu, Yangfan Wang, Yan Zhou, Dandan Yu, Zhiyuan Wang, Linfang He, Zhang‐Peng Chen, Yaliang Zhang, Don Davidson, Yuyuan Dai, Chun‐Hua Hang, Xiangyu Liu, Chao Yan
Abstract
; CANX: calnexin; CASP3: caspase 3; CAT: catalase; CBD: cannabidiol; CQ: chloroquine; DDIT3: DNA damage inducible transcript 3; ER: endoplasmic reticulum; GBM: glioblastoma multiforme; GFP: green fluorescent protein; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; SLC8A1: solute carrier family 8 member A1; SQSTM1: sequestosome 1; TCGA: The cancer genome atlas; TEM: transmission electron microscopy; TMZ: temozolomide; TRIB3: tribbles pseudokinase 3; TRPC: transient receptor potential cation channel subfamily C; TRPV4: transient receptor potential cation channel subfamily V member 4.