Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers
Xiaodong Lian, Ce Gao, Xiaoming Sun, Chenyang Jiang, Kevin Einkauf, Kyra Seiger, Joshua M Chevalier, Yuko Yuki, Maureen P. Martin, Rebecca Hoh, Michael J. Peluso, Mary Carrington, Ezequiel Ruíz-Mateos, Steven G. Deeks, Eric Rosenberg, Bruce D. Walker, Mathias Lichterfeld, Xu G. Yu
Abstract
dysfunction. Together, these results suggest a distinct signature of immune footprints in proviral sequences from ECs.
Topics & Concepts
BiologyImmune systemVirologyViral replicationVirusEpitopeGeneticsViral evolutionAntibodyImmunologyGeneRNAHIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions