Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease
Joseph R. Herdy, Larissa Traxler, Ravi Kant Agrawal, Lukas Karbacher, Johannes C. M. Schlachetzki, Lena Boehnke, Dina Zangwill, Doug Galasko, Christopher K. Glass, Jérôme Mertens, Fred H. Gage
Topics & Concepts
SenescenceBiologyTranscriptomePhenotypeDiseaseNeurodegenerationCell biologyAlzheimer's diseaseEpigeneticsNeurosciencePathologyGene expressionGeneticsGeneMedicineTelomeres, Telomerase, and SenescenceNeuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics