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KIR3DS1 directs NK cell–mediated protection against human adenovirus infections

Johannes M. Jung, Wilhelm Ching, Martin E. Baumdick, Helga Hofmann-Sieber, Jens B. Bosse, Tobias Koyro, Kimberly J. Möller, Lucy H.M. Wegner, Annika Niehrs, Kristina Russu, Mareike Ohms, Wenli Zhang, Anja Ehrhardt, Kevin Duisters, Eric Spierings, Angelique Hölzemer, Christian Körner, Suze A. Jansen, Sven Peine, Ingo Königs, Marc Lütgehetmann, Daniel Pérez, Konrad Reinshagen, Caroline A. Lindemans, Marcus Altfeld, Mirjam E. Belderbos, Thomas Dobner, Madeleine J. Bunders

2021Science Immunology17 citationsDOIOpen Access PDF

Abstract

cells. These findings identify the KIR3DS1/HLA-F axis as a new target for immunotherapeutic strategies against severe HAdV disease.

Topics & Concepts

ImmunologyBiologyImmune systemViremiaTransplantationMedicineVirusSurgeryImmune Cell Function and InteractionVirus-based gene therapy researchHematopoietic Stem Cell Transplantation
KIR3DS1 directs NK cell–mediated protection against human adenovirus infections | Litcius