PKD2/polycystin-2 induces autophagy by forming a complex with BECN1
Daniel Peña‐Oyarzún, Marcelo Rodriguez–Peña, Francesca Burgos‐Bravo, Angelo Vergara, Catalina Kretschmar, Cristian Sotomayor-Flores, César A. Ramírez‐Sarmiento, Humbert De Smedt, Montserrat Reyes, William M. Perez, Vicente A. Torres, Eugenia Morselli, Francisco Altamirano, Christian A.M. Wilson, Joseph A. Hill, Sergio Lavandero, Alfredo Criollo
Abstract
; BCL2/Bcl-2: BCL2 apoptosis regulator; BCL2L1/BCL-XL: BCL2 like 1; BECN1: beclin 1; CCD: coiled-coil domain; EBSS: Earle's balanced salt solution; ER: endoplasmic reticulum; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; GOLGA2/GM130: golgin A2; GST: glutathione s-transferase; LAMP1: lysosomal associated membrane protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; NBR1: NBR1 autophagy cargo receptor; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PKD2/PC2: polycystin 2, transient receptor potential cation channel; RTN4/NOGO: reticulon 4; RUBCN/RUBICON: rubicon autophagy regulator; SQSTM1/p62: sequestosome 1; UVRAG: UV radiation resistance associated; WIPI2: WD repeat domain, phosphoinositide interacting 2.