Nickel-Catalyzed Asymmetric Reductive Dicarbamoylation of Alkenes
Jiaoyang Wu, Chuan Wang
Abstract
Herein we report a nickel-catalyzed asymmetric reductive dicarbamoylation of alkenes, in which tethered carbamoyl chlorides and isocyanates serve as distinct electrophilic carbamoylating agents, providing new access to chiral oxindoles bearing an amide-substituted quaternary stereogenic center.
Topics & Concepts
StereocenterChemistryCatalysisNickelAmideElectrophileCombinatorial chemistryReductive eliminationStereochemistryOrganic chemistryMedicinal chemistryEnantioselective synthesisCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic Chemistry