Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers
Kailash Prasad Prajapati, Bibin G. Anand, Masihuzzaman Ansari, Ashu Bhan Tiku, Karunakar Kar
Abstract
The essential amino acid tryptophan, under physiological conditions, self-assembles into amyloid-mimicking neurotoxic nanostructures, capable of driving amyloid cross-seeding of diverse proteins.
Topics & Concepts
Amyloid (mycology)NanofiberTryptophanBiophysicsChemistryAmyloid diseaseProtein aggregationAmyloid fibrilBiochemistryBiologyNanotechnologyMaterials scienceMedicineAmyloid βAmino acidInternal medicineInorganic chemistryDiseaseSupramolecular Self-Assembly in MaterialsAlzheimer's disease research and treatmentsFolate and B Vitamins Research