What turns CREB on? And off? And why does it matter?
André Steven, Michael Friedrich, Paul Jank, Nadine Heimer, Jan Budczies, Carsten Denkert, Barbara Seliger
Abstract
Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target.
Topics & Concepts
CREBNeuroscienceBiologyGeneticsTranscription factorGeneRNA modifications and cancerMicroRNA in disease regulationMolecular Biology Techniques and Applications