Bisphenol A induces non-alcoholic fatty liver disease by promoting the O-GlcNAcylation of NLRP3
Yonghong Zhang, Shujuan Han, Li Tian, Li Zhu, Feng Wei
Abstract
. Our study reveals that BPA, as an environmental factor, may be involved in the promotion of NAFLD, and that targeting NLRP3 and OGT may inhibit BPA's induction of NAFLD.
Topics & Concepts
PyroptosisFatty liverLipid metabolismChemistryWestern blotInflammasomeNonalcoholic fatty liver diseaseSteatosisSteatohepatitisLipid Metabolism DisorderTriglycerideBiochemistryInternal medicineCholesterolMedicineDiseaseBlood lipidsGeneReceptorLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and DiseaseDiet, Metabolism, and Disease