COX2 regulates senescence secretome composition and senescence surveillance through PGE2
S. Gonçalves, Kelvin Yin, Yoko Itō, Adelyne Chan, Ioana Olan, Sarah Gough, Liam D. Cassidy, Eva Serrão, Stephen Smith, Andrew Young, Masashi Narita, Matthew Hoare
Abstract
play a critical role in senescence, shaping SASP composition, promoting senescence surveillance and tumor suppression in the earliest stages of tumorigenesis.
Topics & Concepts
SenescenceComposition (language)Cell biologyBiologyCellular senescenceGeneticsGenePhenotypePhilosophyLinguisticsRedox biology and oxidative stressTelomeres, Telomerase, and SenescenceCircadian rhythm and melatonin