ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3′ UTR
Qiqi Li, Gang Yang, Bingbing Ren, Xu Liu, Liqin Tang, Qinghua Shi, Ge Shan, Xiaolin Wang
Abstract
mice exhibit disrupted spermatogenesis and reduced testicular circRNA levels. Additionally, expression levels of human ZC3H14 are associated with non-obstructive azoospermia. Our findings reveal a conserved requirement for ZC3H14 in the modulation of backsplicing and link ZC3H14 and circRNA biogenesis to male fertility.
Topics & Concepts
BiologyIntronExonGeneticsUntranslated regionThree prime untranslated regionBoundary (topology)Computational biologyGeneMessenger RNAMathematical analysisMathematicsRNA Research and SplicingRNA modifications and cancerRNA and protein synthesis mechanisms