Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza
Meito Shibuya, Shigeyuki Tamiya, Atsushi Kawai, Toshiro Hirai, Mark S. Cragg, Yasuo Yoshioka
Abstract
The combined use of CpG-ODN and alum improves the efficacy of an influenza vaccine Antibodies and CD4 + T cells synergistically contribute to crossprotection IFN-g from virus-specific CD4 + T cells could confer cross-protection The downregulation of FcgRIIb by IFN-g is associated with crossprotection by antibodies Shibuya et al., iScience 24, 103131
Topics & Concepts
AntibodyVirologyInterferonBiologyChemistryImmunologyImmune Cell Function and InteractionInfluenza Virus Research StudiesMonoclonal and Polyclonal Antibodies Research