Meal sugar-protein balance determines postprandial FGF21 response in humans
Stina Ramne, Lisanne Duizer, Mette S. Nielsen, Niklas Rye Jørgensen, Jens S. Svenningsen, Niels Grarup, Anders Sjödin, Anne Raben, Matthew P. Gillum
Abstract
Here we test the interactions between sugar, protein, and fat in human FGF21 regulation and demonstrate that protein, but not fat, suppresses sugar-induced FGF21 secretion. This indicates that protein outweighs the effects of sugar in the secretory regulation of FGF21, and could suggest that the nutrient-specific appetite-regulatory actions of FGF21 might prioritize ensuring sufficient protein intake over limiting sugar intake.
Topics & Concepts
PostprandialSugarMealBalance (ability)Food scienceAnimal scienceBiologyEndocrinologyDiabetes mellitusNeuroscienceFibroblast Growth Factor ResearchGenetic Syndromes and ImprintingBariatric Surgery and Outcomes