Visible-Light Enabled C(s <i>p</i> <sup>3</sup> )–C(s <i>p</i> <sup>2</sup> ) Cross-Electrophile Coupling via Synergistic Halogen-Atom Transfer (XAT) and Nickel Catalysis
Girish Suresh Yedase, Avishek Kumar Jha, Veera Reddy Yatham
Abstract
We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic halogen atom transfer (XAT) and nickel catalysis. This simple protocol operates under mild reaction conditions and tolerates a variety of functional groups affording C(sp3)–C(sp2) cross-coupling products in good to moderate yields.
Topics & Concepts
ElectrophileNickelCatalysisHalogenChemistryAtom (system on chip)Coupling (piping)Materials scienceOrganic chemistryMetallurgyAlkylComputer scienceEmbedded systemRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods