Human midbrain organoids: a powerful tool for advanced Parkinson’s disease modeling and therapy exploration
Xin Cui, Xinwei Li, Huimin Zheng, Yun Su, Shuyu Zhang, Mengjie Li, Xiaoyan Hao, Shuo Zhang, Zhengwei Hu, Zongping Xia, Changhe Shi, Yuming Xu, Chengyuan Mao
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains unclear. Human midbrain organoids (hMLOs) have emerged as a promising model for studying PD, drug screening, and potential treatments. This review discusses the development of hMLOs, their application in PD research, and current challenges in organoid construction, highlighting possible optimization strategies.
Topics & Concepts
OrganoidParkinson's diseaseMidbrainNeuroscienceMedicineDiseasePsychologyCentral nervous systemInternal medicineNeurological disorders and treatmentsParkinson's Disease Mechanisms and TreatmentsAutism Spectrum Disorder Research