Investigation of the remote acyl group participation in glycosylation from conformational perspectives by using trichloroacetimidate as the acetyl surrogate
Ke Xu, Qingmin Man, Yang Zhang, Jia Guo, Yichu Liu, Zunyun Fu, Yueyue Zhu, Yingxia Li, Mingyue Zheng, Ning Ding
Abstract
The remote acyl group participation in glycosylation was studied by using trichloroacetimidate as the acetyl surrogate. The bridging participation intermediates were systematically trapped, and DFT calculations were applied to explain the results.
Topics & Concepts
ChemistryGlycosylationBridging (networking)Group (periodic table)N-linked glycosylationStereochemistryCombinatorial chemistryComputational chemistryBiochemistryGlycanOrganic chemistryGlycoproteinComputer scienceComputer networkCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchChemical Synthesis and Analysis