Association of body composition with toxicity to first-line chemotherapy and three-year survival in women with ovarian adenocarcinoma
Karine de Aguiar Bruno, Mario Jorge Sobreira da Silva, Gabriela Villaça Chaves
Abstract
BACKGROUND: This study aimed to evaluate the association of body composition with toxicity to first-line chemotherapy and three-year survival in women with ovarian adenocarcinoma. METHODS: grade 3 toxicity, toxicity-induced modification of treatment (TIMT), and three-year survival. RESULTS: grade 3 and TIMT. Also, SMD was the only body composition parameter able to predict reduced three-year survival. The SMI was not associated with any of the outcomes. CONCLUSION: Fewer amounts of SATI and low SMD were associated with the occurrence of toxicity to chemotherapy, and the low SMD increased the risk of death in the three years after oncologic treatment.
Topics & Concepts
MedicineToxicityChemotherapyInternal medicineOncologyAdenocarcinomaEpithelial ovarian cancerOvarian cancerOvarySurgeryGynecologyRetrospective cohort studyCancerGastroenterologyCause of deathRisk factorPerformance statusCancer Risks and FactorsOvarian cancer diagnosis and treatmentMenopause: Health Impacts and Treatments