Spatially heterogeneous epidermal growth factor release from microporous annealed particle (MAP) hydrogel for improved wound closure
Lauren J. Pruett, Regan Ellis, Meghan McDermott, Colleen Roosa, Donald R. Griffin
Abstract
We present lyophilized heparin microgels which can be directly rehydrated with epidermal growth factor and mixed with PEG microgels to form heterogenous MAP scaffolds. These EGF-releasing MAP scaffolds promote accelerated dermal wound healing.
Topics & Concepts
ScaffoldMicroporous materialMaterials scienceEpidermal growth factorGrowth factorWound healingIn vivoSelf-healing hydrogelsBiomedical engineeringBiophysicsNanotechnologyChemistryComposite materialBiochemistryBiologyPolymer chemistryReceptorImmunologyBiotechnologyMedicineWound Healing and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsTendon Structure and Treatment