Path towards mRNA delivery for cancer immunotherapy from bench to bedside
Wenfei Chen, Yining Zhu, Jinhan He, Xun Sun
Abstract
transfection of dendritic cells (DCs) with mRNA and direct injection of mRNA-based therapeutics, either with or without a carrier. This review offers a comprehensive overview of major non-viral vectors employed for mRNA vaccine delivery. It showcases notable preclinical and clinical studies in the field of cancer immunotherapy and discusses important considerations for advancing these promising vaccine platforms for broader therapeutic applications. Additionally, we provide insights into future possibilities and the remaining challenges in mRNA delivery technology, emphasizing the significance of ongoing research in mRNA-based therapeutics.
Topics & Concepts
Cancer immunotherapyMessenger RNAImmunotherapyIn vivoMedicineBench to bedsideComputational biologyBiologyImmunologyImmune systemBiotechnologyMedical physicsGeneBiochemistryRNA Interference and Gene DeliveryImmunotherapy and Immune ResponsesVirus-based gene therapy research