Cryo-EM structures of human calcium homeostasis modulator 5
Jie Liu, Futang Wan, Qiuheng Jin, Xiaoxiao Li, Eijaz Ahmed Bhat, Jiangtao Guo, Ming Lei, Fenghui Guan, Jian Wu, Sheng Ye
Abstract
Calcium homeostasis modulators (CALHMs) are the most recently identified large pore ATP-releasing channels, playing important roles in neuronal functions including gustatory signaling 1 , 2 and neuronal excitability 3 . Dysfunction of CALHMs has been linked to pathologies of depression 4 and Alzheimer’s disease 5 . Therefore, CALHM family proteins have received increasing attention in recent neurobiological studies 6 , 7 . CALHM genes are present throughout vertebrates 5 , and six CALHM homologs have been identified in humans that share an overall 20%–50% sequence similarity 8 .
Topics & Concepts
ChemistryIon channelNeuroscienceMedicineBiologyBiochemistryReceptorBiochemical Analysis and Sensing TechniquesRNA and protein synthesis mechanismsRNA regulation and disease