Reperfused vs. nonreperfused myocardial infarction: when to use which model
Merry L. Lindsey, Lisandra E. de Castro Brás, Kristine Y. DeLeon‐Pennell, Nikolaos G. Frangogiannis, Ganesh V. Halade, Caitlin C. O’Meara, Francis G. Spinale, Zamaneh Kassiri, Jonathan A. Kirk, Petra Kleinbongard, Crystal M. Ripplinger, Keith R. Brunt
Abstract
There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal models of MI. This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research.
Topics & Concepts
Myocardial infarctionMedicineCardiologyInternal medicineAnimal modelIntensive care medicineCardiac Ischemia and ReperfusionCardiac Fibrosis and RemodelingCardiovascular Function and Risk Factors