Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model
Víctor García-Bustos, Amparo Ruiz‐Saurí, Alba Ruiz‐Gaitán, Ignacio Antonio Sigona-Giangreco, Marta Dafne Cabañero-Navalón, Oihana Sabalza-Baztán, Miguel Salavert‐Lleti, María Ángeles Tormo‐Más, Javier Pemán
Abstract
filamentation as an important pathogenic determinant. We also found that it is able to disseminate early through the host, invading both the circulatory system and many different tissues with a remarkable respiratory tropism not previously described for other yeasts. Our study provides new insights into the pathogenicity of an emergent fungal pathogen and its interaction with the host and supports the hypothesis that its morphogenetic variability contributes to its rising global prevalence.
Topics & Concepts
Galleria mellonellaCandida aurisBiologyVirulenceMicrobiologyCandida albicansPathogenCandida parapsilosisCorpus albicansTropismOutbreakVirologyGeneticsAntifungalVirusGeneEntomopathogenic Microorganisms in Pest ControlInsect symbiosis and bacterial influencesHelminth infection and control