Rhodium(III)‐Catalyzed Divergent C−H Functionalization of <i>N</i>‐Aryl Amidines with Iodonium Ylides: Access to Carbazolones and Zwitterionic Salts
Jie Ren, Yang Liu, Chao Pi, Xiuling Cui, Yangjie Wu
Abstract
Abstract We described an Rhodium(III)‐catalyzed divergent C−H bond functionalization of N ‐aryl amidines with iodonium ylides. Carbazolones and zwitterionic salts were diversely constructed through intermolecular annulation and intramolecular proton transfer under the different reaction conditions. This protocol is operationally simple and tolerates a variety of functional groups. The efficient post‐modification of pharmaceutical molecules demonstrates its practicability.
Topics & Concepts
ChemistryAnnulationIntramolecular forceRhodiumSurface modificationArylCatalysisIntermolecular forceDivergent synthesisCombinatorial chemistryMoleculeMedicinal chemistryOrganic chemistryAlkylPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions