Current Advances in Technologies for Single Extracellular Vesicle Analysis and Its Clinical Applications in Cancer Diagnosis
Lei Qiu, Xingzhu Liu, Libo Zhu, Liqiang Luo, Na Sun, Renjun Pei
Abstract
Extracellular vesicles (EVs) have been regarded as one of the most potential diagnostic biomarkers for different cancers, due to their unique physiological and pathological functions. However, it is still challenging to precisely analyze the contents and sources of EVs, due to their heterogeneity. Herein, we summarize the advances in technologies for a single EV analysis, which may provide new strategies to study the heterogeneity of EVs, as well as their cargo, more specifically. Furthermore, the applications of a single EV analysis on cancer early diagnosis are also discussed.
Topics & Concepts
Extracellular vesiclesCancerMicrovesiclesExtracellular vesicleNanotechnologyComputer scienceMedicineBiologyMaterials scienceCell biologymicroRNAInternal medicineBiochemistryGeneExtracellular vesicles in diseaseCell Adhesion Molecules ResearchNanopore and Nanochannel Transport Studies