Transcription Factor MYB as Therapeutic Target: Current Developments
Karl‐Heinz Klempnauer
Abstract
The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research. This review summarizes its molecular functions and current therapeutic approaches aiming to inhibit its oncogenic activity.
Topics & Concepts
MYBTranscription factorCarcinogenesisBiologyCancer researchCell growthComputational biologyCancerCell biologyBioinformaticsGeneticsGeneUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsEndoplasmic Reticulum Stress and Disease