Dual inhibitors of <i>Pseudomonas aeruginosa</i> virulence factors LecA and LasB
Olga Metelkina, Jelena Konstantinović, Andreas Klein, Roya Shafiei, Mario A. Fares, Alaa Alhayek, Samir Yahiaoui, Walid A. M. Elgaher, Jörg Haupenthal, Alexander Titz, Anna K. H. Hirsch
Abstract
Dual inhibitors of two key virulence factors of Pseudomonas aeruginosa , the lectin LecA and the protease LasB, open up an opportunity in the current antimicrobial-resistance crisis.
Topics & Concepts
Pseudomonas aeruginosaVirulenceMicrobiologyVirulence factorDual (grammatical number)Antibiotic resistanceBiologyBacteriaAntibioticsBiochemistryGeneticsGeneLiteratureArtBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesBiochemical and Structural Characterization