Synthesis and Antimalarial Activity of 4-Methylaminoquinoline Compounds against Drug-Resistant Parasite
Vinay Shankar Tiwari, Prince Joshi, Kanchan Yadav, Anamika Sharma, Sushobhan Chowdhury, Ashan Manhas, Niti Kumar, Renu Tripathi, W. Haq
Abstract
has shown 100% parasite inhibition on day 4, and out of five treated mice, two were cured till the end of the experiment. The present study suggests that 4-methylamino substitution is well tolerated for the antiplasmodial activity with reduced toxicity and therefore will be highly useful for the discovery of a new antimalarial agent against drug-resistant malaria.
Topics & Concepts
Plasmodium yoeliiPlasmodium falciparumIn vivoChloroquineIC50In vitroPharmacologyMoietyAmine gas treatingChemistryAntimalarial AgentCytotoxicityStereochemistryMalariaBiologyBiochemistryParasitemiaImmunologyOrganic chemistryBiotechnologyMalaria Research and ControlSynthesis and Catalytic ReactionsComputational Drug Discovery Methods