Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN−OMe
Jingru Wang, Zhiqiang Song, Chen Li, Dong‐Hui Wang
Abstract
A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.
Topics & Concepts
ChemistryAnisoleArylCatalysisLigand (biochemistry)CopperOrganic chemistryTransformation (genetics)Medicinal chemistryCombinatorial chemistryReceptorAlkylGeneBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions