<i>Moringa oleifera and Musa sapientum</i> ameliorated 7,12-Dimethylbenz[a]anthracene-induced upregulations of Ki67 and multidrug resistance 1 genes in rats.
Adelaja Akinlolu, Adeoye Oyetunji Oyewopo, Risikat Eniola Kadir, A Lawal, Jesutolani Ademiloye, Abdullahi Jubril, Mubarak Ameen, Gabriel Ebito
Abstract
OBJECTIVES: (MS) are plants of ethnomedicinal importance. We evaluated the effects of MOF6 (extracted from MO leaves) and MSF1 (extracted from MS suckers) on immunomodulations of Ki67 (proliferation biomarker) and multidrug resistance 1 (MDR1) genes in the liver of rats in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced hepatotoxicity and mutagenesis to determine their antiproliferation, anti-drug resistance, and anticancer potentials. METHODS: ≤ 0.05). RESULTS: ≥ 0.05) of Ki67 and MDR1 in Groups 3-9 compared with Group 2. Therefore, MOF6 and MSF1 ameliorated DMBA-induced hepatotoxicity, abnormal proliferation, and drug resistance. CONCLUSION: MOF6 and MSF1 possess antiproliferation, anti-drug resistance, and anticancer potentials.