Isosteric Ring Exchange as a Useful Scaffold Hopping Tool in Agrochemistry
Clemens Lamberth
Abstract
Replacing one ring in a molecule by a different carba- or heterocycle is an important scaffold hopping manipulation, because biologically active compounds and their analogues, which underwent such a transformation, are often similar in size, shape, and physicochemical properties and, therefore, likely in their potency as well. This review will demonstrate, how isosteric ring exchange led to the discovery of highly active agrochemicals and which ring interchanges have proven to be most successful.
Topics & Concepts
Ring (chemistry)ScaffoldChemistryDrug discoveryStereochemistryTransformation (genetics)Ring sizePotencyCombinatorial chemistryComputer scienceBiochemistryIn vitroOrganic chemistryGeneDatabaseClick Chemistry and ApplicationsPlant tissue culture and regenerationCarbohydrate Chemistry and Synthesis