Decreased ER dependency after acquired resistance to CDK4/6 inhibitors
Masafumi Iida, Daichi Toyosawa, Misato Nakamura, Kouki Tsuboi, Emi Tokuda, Toshifumi Niwa, Takanori Ishida, Shin‐ichi Hayashi
Topics & Concepts
FulvestrantPalbociclibCancer researchEstrogen receptorPI3K/AKT/mTOR pathwayMedicineCyclin-dependent kinaseCell cultureKinaseProtein kinase BCyclin-dependent kinase 6Cyclin-dependent kinase 4CancerPharmacologyCell cycleBreast cancerMetastatic breast cancerInternal medicineBiologySignal transductionCyclin-dependent kinase 2Cell biologyGeneticsAdvanced Breast Cancer TherapiesEstrogen and related hormone effectsPI3K/AKT/mTOR signaling in cancer