Role of the SOS Response in the Generation of Antibiotic Resistance <i>In Vivo</i>
John K. Crane, Cassandra L. Alvarado, Mark D. Sutton
Abstract
The SOS response to DNA damage is a conserved stress response in Gram-negative and Gram-positive bacteria. Although this pathway has been studied for years, its relevance is still not familiar to many working in the fields of clinical antibiotic resistance and stewardship.
Topics & Concepts
SOS responseBiologyMicrobiologyResistomeAntibioticsIn vivoAntibiotic resistanceEscherichia coliGeneticsGeneIntegronAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyPharmaceutical and Antibiotic Environmental Impacts