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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy

Jonathan Chen, Linda T. Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S. Nabel, Samuel S. Freeman, Joshua D. Pirl, Chenyue Lu, Catherine B. Meador, Jaimie L. Barth, Mustafa Sakhi, Alexander L. Tang, Siranush Sarkizova, Colles Price, Nicolas Fernandez, George Emanuel, Jiang He, Katrina van Raay, Jason Reeves, Keren Yizhak, Matan Hofree, Angela Shih, Moshe Sade-Feldman, Genevieve M. Boland, Karin Pelka, Martin J. Aryee, Mari Mino–Kenudson, Justin F. Gainor, Ilya Korsunsky, Nir Hacohen

2024Nature Immunology130 citationsDOIOpen Access PDF

Topics & Concepts

Immune systemStem cellBiologyImmunologyImmunityImmunotherapyCD8C-C chemokine receptor type 7Immune checkpointCCL5Cancer researchChemokineT cellCell biologyIL-2 receptorChemokine receptorImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy | Litcius