Visible-Light-Induced Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Nitriles
Jie Gao, Xian‐Chen He, Yanling Liu, Ke-Rong Li, Jianping Guan, Hong‐Bin Chen, Hao‐Yue Xiang, Kai Chen, Hua Yang
Abstract
Herein, a visible-light-induced nickel-catalyzed cross-coupling of aryl bromide with nitrile has been reported. By utilization of readily available nitriles as carbonyl precursors, a range of structurally diverse aryl ketones were facilely constructed. The synthetic simplicity, mild reaction conditions, and acidic functional group tolerance would broaden the synthetic utilities of this developed protocol as an expedient alternative to Grignard/organolithium protocols.
Topics & Concepts
ArylChemistryNitrileCatalysisNickelBromideCombinatorial chemistryFunctional groupCoupling reactionOrganic chemistryAlkylPolymerRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions