Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration
Isabelle S. Byers, Nicholas Turner, Nicole L. Levine, Alexander L. Lazarides, Daniel R. Evans, Ivan Spasojević, Ping Fan, Sin-Ho Jung, Junheng Gao, Julia D. Visgauss, Brian E. Brigman, William C. Eward
Abstract
= 0.03). This study is the first to comprehensively assess aspects of perioperative prophylaxis for megaprosthetic reconstructions. Extending postoperative antibiotics did not reduce infection risk. We detected a high frequency of cefazolin nonsusceptible organisms among postoperative infections. Additionally, intraoperative antibiotic tissue concentrations may be predictive of later infection. Future studies ought to examine optimal drug choices and dosing strategies.
Topics & Concepts
DosingMedicineAntibioticsDuration (music)DrugIntensive care medicinePharmacologyBiologyMicrobiologyLiteratureArtOrthopedic Infections and TreatmentsSurgical site infection preventionOrthopaedic implants and arthroplasty