Reactive Oxygen Species and Long Non-Coding RNAs, an Unexpected Crossroad in Cancer Cells
Teodor Paul Kacso, Renata Zahu, Alexandru Tirpe, Elina Valeria Paslari, Andreea Nuţu, Ioana Berindan‐Neagoe
Abstract
Long non-coding RNAs (lncRNA) have recently been identified as key regulators of oxidative stress in several malignancies. The level of reactive oxygen species (ROS) must be constantly regulated to maintain cancer cell proliferation and chemoresistance and to prevent apoptosis. This review will discuss how lncRNAs alter the ROS level in cancer cells. We will first describe the role of lncRNAs in the nuclear factor like 2 (Nrf-2) coordinated antioxidant response of cancer cells. Secondly, we show how lncRNAs can promote the Warburg effect in cancer cells, thus shifting the cancer cell's "building blocks" towards molecules important in oxidative stress regulation. Lastly, we explain the role that lncRNAs play in ROS-induced cancer cell apoptosis and proliferation.