Super-enhancer-driven lncRNA-DAW promotes liver cancer cell proliferation through activation of Wnt/β-catenin pathway
Weicheng Liang, Chuan-Jian Shi, Weilong Hong, Panlong Li, Xue Zhou, Weiming Fu, Lizhu Lin, Jinfang Zhang
Abstract
cancer cell growth by activating the Wnt/β-catenin pathway. Finally, Wnt2 amplification was confirmed as a common event in liver cancer, and the expression of lncRNA-DAW was positively correlated with Wnt2 in HCC specimens. Collectively, we are the first to identify lncRNA-DAW as a novel candidate oncogene in liver cancer, and this lncRNA may serve as a novel clinical diagnosis biomarker for liver cancer.
Topics & Concepts
Wnt signaling pathwayCancer researchBiologyCarcinogenesisEnhancerLong non-coding RNAOncogeneEctopic expressionLiver cancerCancerCell cycleRNACell biologyTranscription factorCell cultureHepatocellular carcinomaSignal transductionGeneticsGeneCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing