Absolute content determination by quantitative NMR (qNMR) spectroscopy: a curious case of aldosterone
Neeraj Singh, Judith Taibon, Stephan Pongratz, Christian Geletneky
Abstract
HNMR spectrum, false interpretation of which can have significant effects if such a value is utilized for the primary calibrators in ID-LC-MS/MS ('gold standard') reference methods in clinical chemistry.
Topics & Concepts
AldosteroneChemistryAnalytical Chemistry (journal)SpectroscopyNuclear magnetic resonance spectroscopyAbsolute (philosophy)Content (measure theory)ElectrolyteNuclear magnetic resonanceChromatographyPhysical chemistryPhysicsMathematicsStereochemistryInternal medicineMedicineQuantum mechanicsPhilosophyMathematical analysisEpistemologyElectrodeRenal function and acid-base balanceAnalytical Methods in PharmaceuticalsPesticide Residue Analysis and Safety